Creatine and creatinine metabolism.

Cli. the Metabolism of Creatine Ii. the Conversion of Arginine into Creatine in the Isolated Rabbit Heart

THE use of the whole animal for the study of the metabolism of creatine has a number of disadvantages. A large body of evidence exists which indicates that quite considerable quantities of creatinine may be injected into an animal, or administered parenterally, without the subsequent appearance of any extra creatine in the urine. Furthermore, the recent work of Benedict & Behre [1937] and of Ga...

Excretion of creatinine and creatine by beef steers.

In the classical theory of protein metabolism proposed by Folin (1) two types of protein metabolism are recognized, one a constant or endogenous metabolism, and the other a variable or exogenous metabolism. According to this theory the endogenous metabolism is represented by the excretion of creatinine at a relatively constant rate which is independent of protein intake. More recently, as point...

Excretion of Creatinine and Creatine by Beef

In the classical theory of protein metabolism proposed by Folin (1) two types of protein metabolism are recognized, one a constant or endogenous metabolism, and the other a variable or exogenous metabolism. According to this theory the endogenous metabolism is represented by the excretion of creatinine at a relatively constant rate which is independent of protein intake. More recently, as point...

Guanidino compounds in guanidinoacetate methyltransferase deficiency, a new inborn error of creatine synthesis.

The first inborn error of creatine metabolism (guanidinoacetate methyltransferase [GAMT] deficiency) has recently been recognized in an infant with progressive extrapyramidal movement disorder. The diagnosis was established by creatine deficiency in the brain as detected by in vivo magnetic resonance spectroscopy and by defective GAMT activity and two mutant GAMT alleles in a liver biopsy. Here...

Studies in bacterial metabolism with special reference to creatine and creatinine

Creatine and creatinine metabolism in the normal male adult studied with the aid of isotopic nitrogen.

Experiments designed to demonstrate balance between the amount of creatine ingested and the amount retained or excreted as creatine and creatinine have so far failed in their purpose. The results of such studies have led to the opinion either that there is an end-product of creatine other than creatinine or that the synthesis of endogenous creatine is retarded by exogenous creatine (1). We have...